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. 2024 Jan 23;14:1247232. doi: 10.3389/fgene.2023.1247232

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Copyright © 2024 Szalanczy, Fitzpatrick, Beeson, Bui, Dyson, Eller, Landry, Scott, Grzybowski, Klotz, Geurts, Weiner, Redei and Solberg Woods.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Corticosterone (CORT) response to acute restraint stress in wild-type (WT, black) and Krtcap3 knock-out (KO, gray) rats. (A) Serum basal CORT was measured immediately prior to acute restraint after 10 weeks of the mild stress protocol. Basal CORT was not increased in stress-exposed rats (empty) relative to control counterparts (filled). (B) Serum CORT measurements were also taken after 10 and 30 min of restraint. CORT significantly increased as restraint continued in all rats. ****p < 0.0001 represents effect of time for all groups. (C) After 10 min of restraint, there were no differences in CORT between WT rats, but stress-exposed KO rats had a lower CORT than control KO rats. *p < 0.05 represents effect of stress exposure in KO rats.