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. 2024 Jan 23;15:1258740. doi: 10.3389/fimmu.2024.1258740

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Copyright © 2024 Chen, Zhang, Li, Li, Xie, Weng, Tan, Liu, Guo and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The members of DUB family. According to sequence and structural similarity, DUBs are classified into seven families, including the Ubiquitin-specific proteases (USPs), Ovarian tumor proteases (OTUs), Josephins and JAB1/MPN/Mov34 metalloenzymes (JAMMs), Machado-Josephin disease proteins (MJDs), Ubiquitin carboxyl-terminal hydrolases (UCHs), motif interacting with ubiquitin-containing novel DUB family proteases (MINDYs) and zinc finger-containing ubiquitin peptidase 1 (ZUP1). And the USP family is the largest group of the DUBs.