Table 2.

USPs and pneumonia.

Enzymes	Function	Mechanism	References
USP10	Promoting mucociliary clearance and the removal of pathogens to cure pneumonia	Interacting with the bacterial toxin	(38)
USP11	Deteriorating pneumonia	Deubiquitinating and stabilizing LPA1, enhancing LPA1-mediated proinflammatory effects	(39)
USP14	Promoting pneumonia, increasing the apoptosis of lung epithelial cells	Regulating I-κB stability, increasing the expression of PARP-1 and pro-apoptotic proteins, depressing the expression of anti-apoptotic proteins, inhibiting the lung epithelial cell growth	(40–42)
USP38	Alleviating the pneumonia response and the bleomycin-induced pulmonary fibrosis	Deubiquitinating IL-33 receptor, negatively regulating the IL-33-triggered signaling pathway and autophagic degradation	(37)
CYLD	Exacerbating lung infections, ALI, bacterial translocation, and lethality, inhibiting injury-induced fibrotic responses	Inhibiting NF-κB signaling pathway, suppressing the expression of PAI-1, inhibiting TGF-β signaling pathway	(36, 43–47)