Table 5.

USPs and hepatitis.

Enzymes	Function	Mechanism	References
USP4	Aggravating inflammation and fibrosis in the liver	Regulating TGF-β1 signaling pathway	(74)
USP10	Alleviating hepatic histological steatosis, inflammation, and fibrosis	Promoting autophagy	(75)
USP15	Influencing viral hepatitis, contributing to HCV transmission in hepatocytes	Upregulating the transactivation activity and stability of HBx, regulating viral RNA translation and lipid metabolism	(76–78)
USP18	Stimulating HCV and HBV replication, promoting viral entry and infectivity, promoting hepatic inflammatory responses	Inhibiting IFN-α and utilizing the IFN stimulated gene 15 (ISG15)/USP18 pathway, fostering a cellular environment characterized by CD81 upregulation, attenuating the effects of type I and type III IFNs, deubiquitinating TAK1	(79–92)
USP37	Influencing viral hepatitis	Reacting with the HBx	(78)