Table 6.

USPs and sepsis.

Enzymes	Function	Mechanism	References
USP9X	Promoting sepsis	Leading to the dysfunction of CD8 + T cells	(96)
USP7	Aggravating the detriment of sepsis	Deubiquitinating and upregulating SOX9	(97)
USP10	Alleviating sepsis	Protecting renal tubular epithelial cells from acute kidney injure induced by LPS	(98)
USP14	Promoting the release of cell factors induced by LPS	Interacting with TRAF6; deubiquitinating CBP and stabilizing it	(99)
USP18 and USP19	Alleviating sepsis and improving livability	Preventing the production of IL-6, IL-1β and TNF-α in sepsis, inhibiting the activation of NF-κB via deubiquitinating TAK1	(100, 101)
USP39	Decreasing the release of proinflammation factors and sepsis	Negatively modulating NF-κB signaling pathway; deubiquitinating and stabilizing IκBα	(102)
USP50	Aggravating LPS-induced sepsis	Stabilizing carnitine palmitoyltransferase 1a (CPT1a) and enhancing FAO	(103)