Table 8.
USPs and type 2 diabetes.
| Enzymes | Function | Mechanism | References |
|---|---|---|---|
| USP2 | Altering insulin sensitivity | Depending on adipocyte | (117) |
| USP4 | Reducing insulin resistance | Decreasing the ubiquitination and degradation of insulin receptors | (118) |
| USP7 | Resulting in delayed insulin negative feedback loop and sustained insulin signaling | Participating in the insulin signaling pathway by binding to PiT1 and deubiquitinating the insulin receptor substrate | (119) |
| USP14 | Promoting hyperglycemia and glucose intolerance | Increasing the damage to ER | (120) |
| USP19 | Enhancing obesity and glucose intolerance induced by high-fat diet | Regulating adipogenesis | (121) |
| USP20 | Promoting weight gain induced by diet, upregulating the levels of serum and liver lipid, reducing insulin sensitivity and energy expenditure | Stabilizing HMGCR during the feeding state | (122) |
| USP21 | Promoting obesity and T2D | Inhibiting an oxidized fiber phenotype in skeletal muscle | (123) |
| USP22 | Inhibiting ferroptosis induced by HG | Stabilizing SIRT1 | (124) |
| USP33 | Promoting insulin sensitivity | Mediating ADRB2 deubiquitination | (125) |