Fig. 8. Comparison of ZIKV infection and neurological outcomes in Ifnar^-/- and C57BL/6 + α-IFNAR mouse models.

While both Ifnar^-/- and C57BL/6 mice treated with α-IFNAR blocking antibody (WT + α-IFNAR) are susceptible to systemic ZIKV infection, only Ifnar^-/- mice exhibit ZIKV infection and inflammation in the CNS, resulting in neurological symptoms of hindlimb paralysis.