TABLE 1.
Multiplication of E. chaffeensis in infected tissues of immunocompromised mice
| Day postinfection | No. of infected cells per fielda in:
|
|||
|---|---|---|---|---|
| Liverb
|
Spleen
|
|||
| C.B-17-scid mice | C.B-17-scid/bg mice | C.B-17-scid mice | C.B-17-scid/bg mice | |
| 3 | 0 | 0 | NDc | ND |
| 10 | 1 ± 1 | 0.8 ± 0.83 | ND | ND |
| 17 | 3.2 ± 2.4 | 4.6 ± 1.7 | 7.0 ± 1.3 | 4.9 ± 3.1 |
| 24 | 11.7 ± 4.3 | 2.1 ± 2.1d | 7.3 ± 1.1 | 8.5 ± 4.2 |
a
Values are the means and standard deviations of E. chaffeensis-positive cells detected in the tissues of the indicated strains by immunohistochemistry (5 to 10 fields per group; magnification, ×1,000).
b
Liver sections contained on average 90.5 ± 16.4 hepatocytes/field; spleen sections contained 482 ± 120 cells/field.
c
ND, not determined.
d
Substantial necrosis was present in these tissue sections.