Figure 2.

NF1 deficiency alters global transcription and metabolism-related transcriptomic networks. A) NF1-deficient cells are transcriptionally distinct across cell types and models (n = 3). PCA coordinates were generated using iDEP 9.1. B) NF1 deficiency alters the metabolic transcriptome. GSEA enrichment analysis for metabolism-related KEGG and Reactome pathways. Each bubble represents the pathway enrichment score for each NF1-deficient vs. NF1-WT comparison. The list of metabolism-related KEGG and REACTOME pathways was manually curated from a list of all KEGG and REACTOME pathways in all models.