Table 3.

Dynamic histone modifications in animal models of acute stress.

Species	Paradigm	Measurement Post-stress	Brain Region	Genomic Region	Histone Modification	Further Results	References
Rat	Restraint stress (30 min)	Immediately	Hip (DG, CA1)	Genome-wide	H3K9me3↑	-	Hunter et al., 2009 [60]
Rat	Restraint stress (30 min)	Immediately	Hip (DG, CA1)	Genome-wide	H3K27me3↓	-	Hunter et al., 2009 [60]
Rat	Restraint stress (30 min)	Immediately	Hip (DG, CA1)	Genome-wide	H3K9me1↓	-	Hunter et al., 2009 [60]
Mouse	Acute restraint in chronic restraint stress model (21 days)	2 h	Hip (DG)	Grm2 promoter	P300↑ --> H3K27ac↑	mGlu2 receptors↑	Nasca et al., 2015 [61]
Mouse	Acute restraint in chronic restraint stress model (21 days)	24 h	Hip (DG)	Grm2 promoter	P300↓ --> H3K27ac↓	mGlu2 receptors↓	Nasca et al., 2015 [61]
Rat	Restraint stress (2 h)	2 h	Hip	Bdnf promoter I, IV, VI	H3ac↓	Bdnf mRNA↓	Fuchikami et al., 2009 [62]
Rat	Restraint stress (2 h)	24 h	Hip	Bdnf promoter I, IV and IV	No sign. changes in H3ac	-	Fuchikami et al., 2009 [62]
Rat	Social defeat (4 x 15 min)	30 min	Hip	Genome-wide	H3ac↑	-	Hollis et al., 2010 [63]
Rat	Forced swim (30 min)	1 day	Hip (DG)	Genome-wide	H3ph↑	-	Bilang-Bleuel et al., 2005 [64]
Rat	Predator stress (15 min)	1 day	Hip (DG)	Genome-wide	H3ph↑	-	Bilang-Bleuel et al., 2005 [64]
Rat	Ether exposure (3 min)/ cold stress (4 h)	1 day	Hip (DG)	Genome-wide	No change in H3ph	-	Bilang-Bleuel et al., 2005 [64]
Rat	Acute glucocorticoid treatment	1 h	Hip	Genome-wide	H3K9me3↓	Especially at B2 short interspersed nuclear elements	Bartlett et al., 2021 [65]

Abbreviations: Bdnf: Brain Derived Neurotrophic Factor, CA1: First region in the hippocampal circuit, DG: Dentate gyrus, Grm2: Glutamate metabotropic receptor 2, Hip: Hippocampus, mGlu2: Metabotropic glutamate receptor 2, P300: E1A binding protein p300.