Table 6.

Overview of studies and surveys of Ayahuasca for the treatment of PTSD.

Study First Author, Year	Sample Size	Method	Measures	Study Type	Effect	Statistical Outcome
Perkins et al., 2021 [624]	n = 6,877	Large cross-sectional study of ayahuasca drinkers in > 40 countries who had used ayahuasca in various contexts, assessing associations between set / setting variables, and intermediate and final mental health and well-being outcomes, including perceived change in psychological well-being, number of personal self-insights attained, and subjective spiritual experience (psychedelic-only)	• SF-12 • K10 • Psychological Wellbeing-Post-Traumatic-Changes Questionnaire • PHQ-4 • PGIC • PEQ-S • SIMO	International cross-sectional survey	Positive associations among ceremonial practices, additional supports, and individual motivations with the 6 intermediate outcomes. Support and safety associated with improvements in perceived growth in psychological well-being (PWG). (See article for additional outcomes)	Support and Safety / PWG score: p = 0.000 (see article for all other additional outcomes)

Abbreviations: K10: Kessler Psychological Distress Scale, PEQ-S: Persisting Effects Questionnaire, PGIC: Patient’s Global Impression of Change, PHQ-4: Patient Health Questionnaire for Depression and Anxiety, PTSD: Post-traumatic stress disorder, PWG: Perceived growth in psychological well-being, SF-12: 12-item Short Form Survey, SIMO: Short Index of Mystical Orientation.