Table 2.
ChemRICH set enrichment analysis to identify lipid set associated with liver cancer risk.
| Lipid Class | p-value (ChemRICH) | FDR (ChemRICH) | Significant lipids (FDR < 0.05) | Significant lipids (%) | Set Size | Positive associations (FDR <0.05) | Negative Associations (FDR < 0.05) |
|---|---|---|---|---|---|---|---|
| UFA-TAG (Triacylglycerol) | 2.7E-15 | 7.5E-14 | 20 | 43% | 47 | 17 | 3 |
| SM (Sphingomyelin) | 3.2E-12 | 4.4E-11 | 12 | 80% | 15 | 1 | 11 |
| UFA-SM (Sphingomyelin | 5.8E-12 | 5.4E-11 | 14 | 70% | 20 | 0 | 14 |
| SFA-TAG (Triacylglycerol) | 1.0E-11 | 7.2E-11 | 7 | 58% | 12 | 7 | 0 |
| MUFA-TAG (Triacylglycerol) | 3.3E-11 | 1.8E-10 | 12 | 57% | 21 | 12 | 0 |
| CER (Ceramide) | 7.9E-11 | 3.7E-10 | 15 | 58% | 26 | 2 | 13 |
| CE (Cholesterol ester) | 3.2E-10 | 1.3E-09 | 7 | 64% | 11 | 1 | 6 |
| UFA-PC (Phosphatidylcholine | 2.0E-09 | 6.9E-09 | 9 | 27% | 33 | 8 | 1 |
| plasmPC (Plasmalogen phosphatidylcholine) | 3.2E-08 | 1.0E-07 | 7 | 16% | 44 | 1 | 6 |
| PUFA-TAG (Triacylglycerol) | 1.9E-07 | 5.2E-07 | 7 | 16% | 44 | 4 | 3 |
| UFA-LPC (Lysophosphatidylcholine) | 3.0E-06 | 7.7E-06 | 3 | 75% | 4 | 0 | 3 |
| MUFA (Monounsaturated fatty acid) | 1.8E-05 | 4.1E-05 | 4 | 57% | 7 | 4 | 0 |
| MUFA-PC(Phosphatidylcholine) | 9.8E-05 | 2.1E-04 | 5 | 56% | 9 | 5 | 0 |
| PUFA-PC (Phosphatidylcholine) | 1.1E-04 | 2.1E-04 | 8 | 21% | 38 | 5 | 3 |
| PUFA-LPC (Lysophosphatidylcholine) | 4.3E-04 | 8.0E-04 | 4 | 80% | 5 | 0 | 4 |
| SFA-LPC (Lysophosphatidylcholine) | 5.5E-04 | 9.6E-04 | 3 | 30% | 10 | 0 | 3 |
| PE (Phosphatidylethanolamine) | 1.0E-02 | 1.7E-02 | 2 | 20% | 10 | 2 | 0 |
| AC (Acylcarnitine) | 1.3E-02 | 2.0E-02 | 2 | 18% | 11 | 2 | 0 |
| SFA-PC (Phosphatidylcholine) | 2.2E-02 | 3.3E-02 | 2 | 25% | 8 | 2 | 0 |
| DG (Diglyceride) | 2.6E-02 | 3.6E-02 | 4 | 44% | 9 | 2 | 2 |
| PI (Phosphatidylinositol) | 3.1E-02 | 4.1E-02 | 3 | 38% | 8 | 3 | 0 |
| GlcCer (Glucosylceramide) | 3.5E-02 | 4.4E-02 | 3 | 38% | 8 | 1 | 2 |
MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acid; SFA, saturated fatty acid, UFA, unsaturated fatty acid.