Table 3.
Co-regulatory lipid modules associated with liver cancer risk.
| Module | Size | FDR | Lipids | DIR |
|---|---|---|---|---|
| M10 | 9 | 1.8E-18 | SM (36:1,37:1,38:1,39:1,40:1,41:1,41:2,41:4,43:4) | ↓ |
| M52 | 4 | 9.2E-15 | SM (36:3,38:2,40:2 B,40:3) | ↓ |
| M54 | 4 | 1.0E-12 | Cer 43:1 SM (43:1, 43:2,41:1) | ↓ |
| M18 | 7 | 6.1E-12 | DG (34:1,36:1) TAG(52:1,54:1,54:2,56:2,56:3) | ↑ |
| M36 | 5 | 7.1E-11 | TAG (44:0,44:1,46:0,48:0,50:0,40:0) | ↑ |
| M12 | 9 | 1.2E-10 | TAG(54:0,55:1,57:1,57:2,58:0,59:2,59:3,60:1,62:2) | ↑ |
| M11 | 9 | 1.7E-10 | TAG (56:1,58:1,58:2,58:3,58:4,58:5,60:2,60:3,60:4) | ↑ |
| M25 | 7 | 9.0E-08 | PC (40:5 B,38:2,40:4,42:5,42:6) TAG (46:5,60:6) | ↑ |
| M61 | 4 | 2.1E-07 | Cer 34:2 SM(32:2,34:2,36:2) | ↓ |
| M69 | 4 | 3.2E-07 | Cer 44:1, GlcCer14:14E/20:02OH,SM(42:1, 42:2 B) | ↓ |
| M13 | 8 | 9.7E-07 | CE 16:1, LPC 16:1, PC (32:1,34:1,36:1,36:4 B,38:4 B) PI 36:1 | ↑ |
| M9 | 9 | 1.0E-06 | Cer (38:1,39:1,40:1,40:2,41:1,38:1,40:1,41:1) SM 40:4 | ↓ |
| M43 | 5 | 5.3E-06 | PC 28:0,PC 30:0,PC 30:1,PC 32:0,PC 32:3 | ↑ |
| M20 | 7 | 9.3E-06 | FA (14:0,14:1,16:0,16:1,18:1,20:1,20:3) | ↑ |
| M2 | 10 | 1.4E-05 | DG (36:3,36:4 A) TAG(51:5,52:3,52:4,52:5,54:4,54:5 A,54:6 A,54:7 A) | ↓ |
| M65 | 4 | 1.4E-05 | plams PC(34:1e,38:4e,32:0,32:0) | ↑ |
| M26 | 6 | 1.6E-05 | TAG(40:0,40:1,42:0,42:1,42:2,44:2) | ↑ |
| M73 | 3 | 1.0E-04 | plasmPC(34:2,34:2,36:2) | ↓ |
| M31 | 6 | 3.5E-04 | CE(16:0,18:1,18:2,18:3,20:3,20:4) | ↓ |
| M59 | 4 | 9.4E-04 | LPC(15:0,16:0), plasmLPC(16:0,18:0) | ↓ |
| M72 | 3 | 9.4E-04 | Cer (34:0,40:0,42:0) | ↑ |
| M14 | 8 | 9.4E-04 | Cer (32:1,33:1) SM (30:1,32:0,32:1,33:1,40:2 A,41:2 A) | ↓ |
| M45 | 5 | 1.1E-03 | PC(35:2,33:2,35:2 A,35:2 B,37:2) | ↓ |
| M7 | 10 | 1.1E-03 | plasmPC (38:3,40:3,40:4,34:0e,38:2,38:3,40:3,40:4,42:3) GlcCer d34:1 | ↓ |
| M17 | 7 | 1.1E-03 | TAG(45:1,53:1,47:0, 47:0,49:0,50:1,51:0, 51:0,51:1,53:1) | ↑ |
| M37 | 5 | 1.1E-03 | TAG (51:3,51:4,53:3,53:4,53:5) | ↓ |
| M40 | 5 | 1.5E-03 | plasmPC (34:1,36:1,36:2,34:1,36:1) | ↓ |
| M83 | 3 | 3.7E-03 | TAG (62:1, 62:3, 62:4) | ↑ |
| M8 | 9 | 4.0E-03 | TAG(46:1,46:2,47:2, 47:2,48:1,48:2,49:1,49:2,49:3,50:2) | ↑ |
| M48 | 5 | 7.7E-03 | PC 34:0,PC 35:4,PC 37:4,PC 39:4,TAG 55:5 TAG 17:0–18:1–20:4 | ↑ |
| M60 | 4 | 1.1E-02 | Cer (42:1,42:2 B,42:1,42:2 B) | ↓ |
| M76 | 3 | 1.1E-02 | PC(37:6,39:6,42:6) | ↓ |
| M67 | 4 | 1.1E-02 | CE 22:6 plasmPC(38:5,38:6,40:6) | ↓ |
| M79 | 3 | 1.2E-02 | PC(34:2,34:3 A,36:3 A) | ↑ |
| M3 | 10 | 1.3E-02 | DG 36:2 PC (35:1,37:3,38:4 A) TAG (51:2,52:2, 52:2,53:2,54:3,55:2,55:3) | ↑ |
| M27 | 6 | 1.4E-02 | AC(10:0,12:0,12:1,14:1,16:0,18:0) | ↑ |
| M19 | 7 | 1.6E-02 | PI 34:2 PC (34:3 C,36:2,36:3 B,38:3,38:5,38:5,38:6 C) | ↑ |
| M71 | 4 | 1.7E-02 | SM d39:2 CE(18:0,22:2) TAG(52:2,52:2) | ↓ |
| M4 | 10 | 2.3E-02 | TAG(47:1,54:8,56:7 B,56:8, B,56:9,56:9,58:10,58:8,58:9,60:11) | ↓ |
| M23 | 7 | 2.5E-02 | PE (34:1,36:2,36:3,38:4 B,34:2,36:1,38:4) | ↑ |
| M1 | 10 | 2.6E-02 | CE 20:5 LPC 20:5 PC(36:5 B, 34:5,35:5,36:5,36:5D,37:5,38:5 B,38:7) | ↓ |
| M53 | 4 | 2.6E-02 | plasmPC(36:5,38:5 B,36:5,38:5 B) | ↓ |
| M39 | 5 | 3.8E-02 | TAG(42:3,46:3 A,46:4 A,48:4 A,48:5) | ↑ |
| M15 | 7 | 4.0E-02 | LPC(18:0 A,18:0 B,20:1, 20:0, 20:1, 20:2,18:0) | ↓ |
| M6 | 10 | 4.0E-02 | TAG (50:6,50:6,52:6,52:6,53:5,54:6 C,54:7,55:6,58:10,58:7) | ↑ |
| M80 | 3 | 4.7E-02 | PC(40:7,40:7 B,42:7) | ↑ |
| M46 | 5 | 4.7E-02 | LPC (17:1,22:6,18:1,18:3,22:5) | ↓ |
Note: DIR column shows the overall direction of most lipids in the correlation module.