表 1.

患者的基线临床资料

Baseline data of patients

Case	Gender	Age/years	Primary disease	Concomitant disease	Chemotherapeutics		Stage of MRONJ	Clinical manifestation	Imaging manifestation
					Anti-bone resorption drugs/months	Else
1	Female	63	Lung cancer	-	Zoledronic acid/26, denosumab/2	Crizotinib capsule	2	Soft tissue fistula	Local thickening of bone
2	Male	71	Prostatic cancer	-	Zoledronic acid/31	Flutamide tablets, leuprorelin acetate, microspheres for injection	2	Soft tissue fistula	Diffuse sclerosis of bone
3	Female	40	Breast cancer	-	Zoledronic acid/30, pamidronate/28	Palbociclib, fulvestrant, everolimus tablets	2	Soft tissue fistula	Local thickening of bone
4	Female	64	Osteoporosis	-	Alendronate sodium/48, zoledronic acid/1	-	1	Soft tissue fistula	Sequestration
5	Female	79	Osteoporosis	-	Zoledronic acid/60	-	1	Soft tissue fistula	Sequestration，diffuse sclerosis of bone
6	Female	87	Osteoporosis	Diabetes	Alendronate sodium/103	Acarbose tablets	1	Soft tissue fistula	Sequestration，diffuse sclerosis of bone
7	Female	85	Osteoporosis	-	Alendronate sodium/41	-	1	Soft tissue fistula	Diffuse sclerosis of bone
8	Female	63	Lung cancer	-	Zoledronic acid/57	-	2	Soft tissue fistula	Sequestration，diffuse sclerosis of bone
9	Female	63	Breast cancer	Diabetes	Zoledronic acid/64, denosumab/5	Trastuzumab, pertuzumab, paclitaxel, fulvestrant, capecitabine tablets	2	Soft tissue fistula	Diffuse sclerosis of bone
10	Female	70	Osteoporosis	Hypertension	Zoledronic acid/40, alendronate sodium/48	-	1	Soft tissue fistula	Sequestration
11	Female	74	Osteoporosis	Coronary heart disease	Denosumab/24	Leiflunomide tablets, tripterygium glycosides tablets,	1	Bone exposure	Sequestration，diffuse sclerosis of bone
12	Female	52	Breast cancer	-	Zoledronic acid/30	Letrozole tablets, fulvestran, abemaciclib	2	Soft tissue fistula	Uneven alveolar bone density
13	Female	56	Osteoporosis	Sicca syndrome	Alendronate sodium/36	Prednisone acetate tablets	1	Soft tissue fistula	Sequestration，diffuse sclerosis of bone