Table 2.
Mean a ECG Parameters and Blood Pressures in Patients Treated With ChEIs
Baseline | Donepezil 10 mg/d | P value | Baseline | Rivastigmine 10 cm2/day | P value | Baseline | Galantamine 24 mg/d | P value | |
---|---|---|---|---|---|---|---|---|---|
HR, beat/min | 77 ± 13 | 73 ± 12 | NS | 74 ± 16 | 70 ± 12 | 0.033 | 72 ± 14 | 69 ± 10 | NS |
PR, ms | 163 ± 23 | 163 ± 28 | NS | 174 ± 34 | 177 ± 31 | NS | 166 ± 28 | 169 ± 23 | NS |
QRS, ms | 88 ± 22 | 89 ± 23 | NS | 92 ± 21 | 94 ± 19 | NS | 94 ± 22 | 96 ± 21 | NS |
QT, ms | 373 ± 46 | 382 ± 34 | NS | 392 ± 44 | 402 ± 39 | 0.023 | 395 ± 41 | 400 ± 36 | NS |
QTc, ms | 417 ± 28 | 420 ± 29 | NS | 427 ± 31 | 431 ± 38 | NS | 425 ± 30 | 425 ± 27 | NS |
SBP, mm Hg | 128 ± 15 | 125 ± 17 | NS | 133 ± 17 | 132 ± 18 | NS | 138 ± 17 | 142 ± 23 | NS |
DBP, mm Hg | 77 ± 7 | 78 ± 9 | NS | 79 ± 10 | 75 ± 9 | NS | 80 ± 8 | 75 ± 10 | NS |
Abbreviations: HR, heart rate; PR, PR interval; QRS, QRS duration; QT, QT interval; QTc, corrected QT interval; SBP, systolic blood pressure; DBP, diastolic blood pressure; ChEI, cholinesterase inhibitor; ECG, electrocardiograms; NS, nonsignificant.
a Mean ± SD, P > .05.