FIG. 2.

Skin tissue sections from mice 48 h after inoculation in air pouches with 10⁹ CFU of S. pyogenes A-20 (A), SW507 (B), NZ131 (C), SW510 (D), A-20 in mice pretreated with vinblastine (E), and SW507 in mice pretreated with vinblastine (F). Magnification, ×24 (A, B, E, and F) and ×60 (C and D). The epidermis, subcutaneous fat, and muscle fibers were severely damaged or destroyed in skin tissues infected by wild-type strains with or without vinblastine pretreatment but not in those infected by the speB mutants.