Table 1.
Sociodemographic Characteristics of Participants, Mean Scores on the Neuropsychological Screening Tests and, According to Diagnostic Groups, Statistical Tests for Their Differences.
| aMCIsd (N = 28) | aMCImd (N = 23) | Healthy Control (N=53) | aMCI vs HC | aMCImd vs HC | aMCI vs aMCImd | |
|---|---|---|---|---|---|---|
| Age, years | 69.89 ± 5.17 | 73.91 ± 4.72 | 68.06 ± 5.96 | NS | NS | NS |
| Gender (F/M) | 17/11 | 15/8 | 29/24 | |||
| Education, years | 9.46 ± 5.21 | 5.74 ± 3 | 9.7 ± 4.31 | NS | NS | NS |
| CDR (0/0.5) | 6/22 | 3/20 | 53/0 | |||
| MMSE | 26.15 ± 2.03 | 25.35 ± 3.23 | 28.19 ± 1.88 | <.001 | <.001 | NS |
| ADL | 5.82 ± 0.48 | 5.87 ± 0.34 | 5.98 ± 0.14 | NS | NS | NS |
| IADL | 7.77 ± 0.59 | 7.74 ± 0.69 | 7.94 ± 0.23 | NS | NS | NS |
| Geriatric Depression Scale | 9.07 ± 6 | 10.65 ± 4.56 | 4.36 ± 3.37 | <.001 | <.001 | NS |
| Short Story Immediate Recall | 5.96 ± 3.46 | 4.7 ± 2.01 | 12.55 ± 5.65 | <.001 | <.001 | NS |
| Short Story Delayed Recall | 8.57 ± 4.07 | 7 ± 3.98 | 14.91 ± 4.17 | <.001 | <.001 | NS |
| Rey’s 15 Words Immediate Recall | 31.21 ± 7.5 | 32.3 ± 6.79 | 39.91 ± 6.27 | <.001 | <.001 | NS |
| Rey’s 15 Words Delayed Recall | 4.46 ± 1.1 | 3.91 ± 1.31 | 8.3 ± 2.57 | <.001 | <.001 | NS |
| Rey’s Complex Figure Delayed Recall | 10.25 ± 3.11 | 9.13 ± 4.44 | 17.02 ± 4.91 | <.001 | <.001 | NS |
| Digit Span | 4.89 ± 0.83 | 4.65 ± 0.78 | 5.42 ± 1.01 | NS | <.001 | NS |
| Corsi Block | 4.54 ± 0.88 | 5.04 ± 0.82 | 5.79 ± 5.26 | NS | NS | NS |
| Rey’s Complex Figure Copy | 29.75 ± 2.98 | 26.39 ± 8.41 | 29.36 ± 5.65 | NS | NS | NS |
| Visual Search (Attentive Matrices) | 42.86 ± 7.26 | 41.52 ± 6.16 | 47.11 ± 12.46 | NS | NS | NS |
| Trail Making Test A | 63.11 ± 24.03 | 119.57 ± 63.02 | 55.04 ± 22.43 | NS | <.001 | <.001 |
| Boston Naming Test | 115.75 ± 3.35 | 116.13 ± 3.45 | 115.62 ± 14.19 | NS | NS | NS |
| Token Test | 30.48 ± 1.24 | 29.35 ± 1.56 | 30.8 ± 2.29 | NS | <.05 | NS |
| Frontal Assessment Battery | 16.11 ± 1.69 | 13.7 ± 1.33 | 16.13 ± 1.13 | NS | <.001 | <.001 |
| Phonological Word Fluency | 28 ± 8.66 | 29.17 ± 8.23 | 30.98 ± 15.64 | NS | NS | NS |
| Semantic Word Fluency | 19.14 ± 7.12 | 16.39 ± 6.11 | 20.19 ± 7.21 | NS | NS | NS |
| Trail Making Test B | 171.13 ± 59.52 | 242.26 ± 70.28 | 148.37 ± 50.17 | NS | <.05 | <.05 |
| Clock Drawing Test | 8.77 ± 1.28 | 6.26 ± 2.85 | 9.11 ± 1.7 | NS | <.001 | <.001 |
Abbreviations: MCI, mild cognitive impairment; aMCIsd, amnestic MCI single domain; aMCImd, amnestic MCI multiple domain; HC, healthy controls; CDR, Clinical Dementia Rating; MMSE, Mini-Mental State Examination; ADL, activities of daily living; IADL, instrumental ADL; NS, not significant.