Table 1.
Comparison data of six assays vs. all-assays median values of CEA results for 40 individual serum samples.
| Measuring system | Regression parameters |
||||||
|---|---|---|---|---|---|---|---|
| Slope (95 % CI) | Intercept (95 %CI） | Cusum test | rs (95 %CI） | Average bias, mg/L (95 % CI) | Average bias, % (95 % CI)a |
CCC (95 %CI） | |
| Abbott Architect i2000 |
1.0201 (1.000–1.0422) | 0.0913 (−0.1325 - 0.4250) | P = 0.53 | 0.996 (0.993–0.998) | 2.97 (−0.29 - 6.23) | 1.67 (−1.78 - 5.12) | 0.9990 (0.9982–0.9994) |
| Autolumo A2000 |
0.9184 (0.8954–0.9363) | 2.3815 (1.8409–3.2455) | P = 0.15 | 0.998 (0.997–0.999) | −19.30 (−39.74 - 1.15) | 6.16 (0.46–11.86) | 0.9448 (0.9293–0.9570) |
| Beckman DxI800 |
1.1462 (1.0845–1.2054) | −0.4720 (−1.2793 - 0.3001) | P = 0.97 | 0.998 (0.997–0.999) | 18.97 (2.10–35.84) | 13.18 (8.47–17.89) | 0.9737 (0.9556–0.9844) |
| Diasorin Liaison XL |
1.0508 (1.0209–1.0984) | −08629 (−1.3395 to −0.4254) | P = 0.15 | 0.997 (0.995–0.999) | 7.26 (0.80–13.73) | 1.50 (−1.79 - 4.78) | 0.9958 (0.9925–0.9976) |
| Maccura IS1200 |
0.9804 (0.9504–1.0189) | −0.3010 (−0.7041 - 0.0813) | P = 0.15 | 0.997 (0.994–0.998) | −1.72 (−12.64 - 9.21) | −4.17 (−7.34 to −1.00) | 0.9891 (0.9797–0.9942) |
| Roche Cobas E601 |
0.8617 (0.8208–0.8883) | 0.7981 (0.4616–1.2332) | P = 0.53 | 0.999 (0.997–0.999) | −19.72 (−36.83 to −2.61) | −9.00 (−11.86 to −6.13) | 0.9614 (0.9489–0.9709) |
a
Assays not fulfilling optimal bias analytical quality specifications are in bold. CCC, concordance correlation coefficient.