Table 1.
Baseline characteristics
| Overall | Thiamine < 8 nmol/L | |||||
|---|---|---|---|---|---|---|
| Variable | Total (n = 158) | Thiamine (n = 73) | Placebo (n = 85) | Total (n = 46) | Thiamine (n = 19) | Placebo (n = 27) |
| Demographics | ||||||
| Age (median, IQR) | 70 (60, 79) | 72 (60, 82) | 70 (60, 78) | 65 (57, 78) | 67 (52, 78) | 65 (58, 75) |
| Female, n (%) | 73 (46%) | 37 (51%) | 36 (42%) | 24 (52%) | 9 (47%) | 15 (56%) |
| Race, n (%) | ||||||
| Black/African American | 14 (9%) | 6 (8%) | 8 (9%) | 5 (11%) | 2 (11%) | 3 (11%) |
| White | 120 (76%) | 56 (77%) | 64 (75%) | 32 (70%) | 14 (74%) | 18 (67%) |
| Unknown/other | 24 (15%) | 11 (15%) | 13 (15%) | 9 (20%) | 3 (16%) | 6 (22%) |
|
BMI (median, IQR) |
27.9 (24.2, 34.3) |
28.3 (23.8, 34.6) |
27.6 (24.7, 34.3) |
27.9 (24.8, 34.2) |
28.1 (22.1, 32.7) |
27.5 (25.2, 36.0) |
| Past medical history | ||||||
| CAD, n (%) | 32 (20%) | 14 (19%) | 18 (21%) | 6 (13%) | 3 (16%) | 3 (11%) |
| CHF, n (%) | 28 (18%) | 11 (15%) | 17 (20%) | 6 (13%) | 1 (5%) | 5 (19%) |
| Dementia, n (%) | 10 (6%) | 6 (8%) | 4 (5%) | 5 (11%) | 3 (16%) | 2 (7%) |
| Diabetes, n (%) | 50 (32%) | 27 (37%) | 23 (27%) | 12 (26%) | 6 (32%) | 6 (22%) |
| Pulmonary disease/COPD, n (%) | 20 (13%) | 11 (15%) | 9 (11%) | 3 (7%) | 1 (5%) | 2 (7%) |
| CKD, n (%) | 28 (18%) | 14 (19%) | 14 (16%) | 8 (17%) | 4 (21%) | 4 (15%) |
| Laboratory values, interventions, and illness severity | ||||||
|
Creatinine (median, IQR) |
1.9 (1.4, 2.7) |
1.9 (1.2, 2.5) |
2.0 (1.5, 2.7) |
1.7 (1.1, 3.0) |
1.2 (1.0, 3.0) |
1.8 (1.2, 3.0) |
|
Lactate (median, IQR) |
3.4 (2.5, 4.7) |
3.1 (2.4, 4.5) |
3.4 (2.6, 4.7) |
3.2 (2.6, 4.5) |
2.9 (2.3, 4.1) |
3.4 (2.6, 4.7) |
| Vasopressor administered | 158 (100%) | 73 (100%) | 85 (100%) | 46 (100%) | 19 (100%) | 27 (100%) |
|
SOFA score (mean ± SD) |
10.6 ± 3.7 | 10.3 ± 3.6 | 10.8 ± 3.8 | 10.2 ± 3.7 | 10.1 ± 3.4 | 10.2 ± 4.0 |
|
Mechanical ventilation, n (%) |
101 (64%) | 49 (67%) | 52 (61%) | 30 (65%) | 14 (74%) | 16 (59%) |
Definition of abbreviations: BMI = body mass index; CAD = coronary artery disease; CHF: congestive heart failure; COPD: chronic obstructive pulmonary disease; CKD = chronic kidney disease; SOFA = sequential organ failure assessment