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. 2024 Feb 5;22:57. doi: 10.1186/s12916-024-03264-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Distribution and levels of MLL1 and STB markers in human placental villi. A-B Immunohistochemical analysis of MLL1 (A) and HCG (B) staining in pregnant women during the first trimester (n = 6), third trimester (n = 6), and preeclampsia (n = 6). C-G mRNA levels of MLL1 (n = 15), MEN1 (n = 15), and STB (n = 9) markers in women with preeclampsia and healthy controls. H-J Western blots (H) and corresponding quantification (I and J) of MLL1 and HCG in the PE (n = 6) and control women (n = 6). K The MLL1 protein level correlated negatively with the protein level of HCG in placental villi. Data are presented as the means ± SD. **P < 0.01, *P < 0.05. HC, healthy control; PE, preeclampsia; CTB, cytotrophoblast; MEN1, menin