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. 2024 Feb 5;22:57. doi: 10.1186/s12916-024-03264-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — MLL1 knockdown in BeWo cells leads to downregulation of the Hippo signaling pathway. A Volcano plot showing differentially expressed genes after MLL1 knockdown or FSK treatment. B Differentially expressed gene sets with either upregulation or downregulation in both the siMLL and FSK groups. C KEGG analyses conducted on 798 genes that were identified as differentially expressed after MLL1 knockdown and are associated with the syncytialization process. D GSEA plot showing the enrichment of Hippo signaling pathway genes in the siMLL group compared with that in the NC group. E The relative expression of core regulators in the Hippo signaling pathway. F GSEA plot showing the enrichment of diseases related to placental development in the siMLL group compared with those in the NC group. Data are presented as the means ± SD. **P < 0.01. KEGG, Kyoto Encyclopedia of Genes and Genomes; GSEA, gene set enrichment analysis; NC, negative control; NES, normalized enrichment score; LATS1, large tumor suppressor kinase 1; SAV1, salvador family WW domain containing protein 1; MOB1A, MOB kinase activator 1A; TEAD, TEA domain transcription factor