Table 3A:
Adjusted odds ratios comparing neonatal cytokine and chemokine concentrations in ASD, DD, and TD in one model, N=398a
Cytokine or Chemokine | ASD vs. TD | ASD vs. DD | DD vs. TD | ||||||
---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | |
CTACK | 0.40 | (0.21, 0.77) | 0.01 | 0.49 | (0.21, 1.14) | 0.10 | 0.82 | (0.35, 1.94) | 0.65 |
MPIF-1 | 0.95 | (0.62, 1.45) | 0.81 | 2.38 | (1.42, 3.98) | 0.001 | 0.40 | (0.24, 0.68) | 0.001 |
MIF | 0.59 | (0.24, 1.48) | 0.26 | 1.21 | (0.65, 2.25) | 0.56 | 0.49 | (0.18, 1.34) | 0.17 |
Multinomial logistic regression model was adjusted for maternal education, gestational age, child’s age at blood spot collection, and years from blood spot collection to elution; cytokines/chemokines were ln-transformed and normalized for total protein (pg/mg total protein); OR represents the fold change in the odds of having one diagnosis relative to another diagnosis or no diagnosis for every 1-unit increase in the ln-transformed cytokine/chemokine (or for every e-fold increase in cytokine/chemokine levels); 398 participants comprised the following groups: 171 ASD, 69 DD and 158 TD; OR = adjusted odds ratio, CI = confidence interval