Table 3C:

Adjusted odds ratios comparing neonatal cytokine and chemokine concentrations in ASD (high, low cognitive and adaptive functioning), DD, and TD in one model, N=398^a

Cytokine or Chemokine	ASDhi vs. ASDlo			ASDhi vs. TD			ASDlo vs. TD
	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
CTACK	0.67	0.21, 2.09	0.49	0.29	0.09, 0.91	0.03	0.43	0.22, 0.84	0.01
MPIF-1	1.64	0.72, 3.72	0.24	1.45	0.63, 3.32	0.38	0.89	0.57, 1.37	0.59
MIF	0.93	0.33, 2.60	0.89	0.56	0.16, 1.94	0.36	0.60	0.24, 1.52	0.28
Cytokine or Chemokine	ASDhi vs. DD			ASDlo vs. DD			DD vs. TD
	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
CTACK	0.35	0.10, 1.26	0.11	0.52	0.22, 1.23	0.14	0.82	(0.35, 1.94)	0.65
MPIF-1	3.64	1.50, 8.84	0.004	2.22	1.31, 3.76	0.003	0.40	(0.24, 0.68)	0.001
MIF	1.14	0.41, 3.16	0.80	1.22	0.62, 2.37	0.56	0.49	(0.18, 1.34)	0.17

^aMultinomial logistic regression model was adjusted for maternal education, gestational age, child’s age at blood spot collection, and years from blood spot collection to elution; cytokines/chemokines were ln-transformed and normalized for total protein (pg/mg total protein); OR represents the fold change in the odds of having one diagnosis relative to another diagnosis or no diagnosis for every 1-unit increase in the ln-transformed cytokine/chemokine (or for every e-fold increase in cytokine/chemokine levels); 398 participants comprised the following groups: 27 ASD-high, 144 ASD-low, 69 DD and 158 TD; OR = adjusted odds ratio, CI = confidence interval