Figure 8.

Nucleophosmin/nucleoplasmin 3-related gene enrichment analysis. (A) A STRING PPI network for NPM3. Colored nodes represent experimentally confirmed proteins that interact with NPM3. (B) Correlations of NPM3 with the top-5 related genes in a heatmap. (C) KEGG enrichment analysis based on NPM3-binding and interacting genes. (D) GO analysis based on NPM3-interacting and correlated genes. ACC: Adrenocortical carcinoma; BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; ccRCC: Clear cell renal cell carcinoma; CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; DLBCL: Lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; GO: Gene Ontology; HNSC: Head and neck squamous cell carcinoma; KEGG: Kyoto Encyclopedia of Genes and Genomes; KICH: Kidney chromophobe; KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LAML: Acute myeloid leukemia; LGG: Lower grade glioma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; MECO: Mesothelioma; NPM3: Nucleophosmin/nucleoplasmin 3; OV: Ovarian serous cystadenocarcinoma; PAAD: Pancreatic adenocarcinoma; PCPG: Pheochromocytoma and paraganglioma; PPI: Protein–protein interaction; PRAD: Prostate adenocarcinoma; READ: Rectum adenocarcinoma; SARC: Sarcoma; SKCM: Skin cutaneous melanoma; STAD: Stomach adenocarcinoma; TGCT: Testicular germ cell tumors; THCA: Thyroid carcinoma; THYM: Thymoma; UCEC: Uterine corpus endometrial carcinoma; UCS: Uterine Carcinosarcoma; UVM: Uveal melanoma.