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. 2022 Sep 27;1(1):56–66. doi: 10.1016/j.cpt.2022.09.001

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© 2022 Published by Elsevier B.V. on behalf of Chinese Medical Association (CMA).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Mechanisms underlying aerobic glycolysis, OXPHOS, and PPP regulation by HIF-1 in radioresistance. ADP: Adenosine diphosphate; ATP: Adenosine triphosphate; CAIX: Carbonic anhydrase 9; G6PD: Glucose-6-phosphate dehydrogenase; GLUT: Glucose transporters; GSH: Glutathione; GSSG: Glutathione disulfide; HIF-1: Hypoxia-inducible factor-1; HK: Hexokinase; LDHA: Lactate dehydrogenase A; MCT4: Monocarboxylate transporter 4; NHE1: Naþ/Hþ exchanger isoform 1; OXPHOS: Oxidative phosphorylation; PDH: Pyruvate dehydrogenase; PDK: Pyruvate dehydrogenase kinase; PPP: Pentose phosphate pathway; ROS: Reactive oxygen species.