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. 2023 Oct 31;34(12):ar114. doi: 10.1091/mbc.E23-02-0062

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FIGURE 3: — rDNA cosegregated with the fibrillar-center proteins (fibrillarin or UBF) in cap-structures in segregated nucleoli. A) Eleven guide RNAs complementary to the rDNA were coexpressed with dCas9-GFP (Ma et al., 2015). The labeled rDNA redistributed with the fibrillar components to nucleolar caps in RPA194 knockdown cells (arrows) similarly to those subjected to low actinomycin D (arrows). B) rDNA and UBF localization after actinomycin treatment. C) Quantitative evaluation demonstrated the copartitioning of rDNA with the fibrillar components in the majority of cells after RPA194 knockdown or low actinomycin D treatment. Bars = 5 µm. A minimum of 100 cells were examined in all cases.