Fig. 1.

Plasma pharmacokinetics of ¹²⁵I-Aβ₄₀ and ¹²⁵I-Aβ₄₂ in WT and APP/PS1 mice at 8, 24, and 52 weeks. WT or APP/PS1 transgenic mice were bolus injected with 100Ci of ¹²⁵I-Aβ₄₀ (A, C) or ¹²⁵I-Aβ₄₂ (B, D) into the femoral vein. Plasma was sampled periodically between 0–15min, and radioactivity in the intact ¹²⁵I-Aβ fraction was measured. The plasma concentration versus time data was fit to a bi-exponential equation. Shown are the observed values (mean±SD, n=3–5) overlaid on the predicted curves.