Fig. 2.

Brain uptake of ¹²⁵I-Aβ₄₀ and ¹²⁵I-Aβ₄₂ in WT and APP/PS1 mice at 8, 24, and 52 weeks. A) Experiment scheme. WT or APP/PS1 transgenic mice were bolus injected with 100Ci of ¹²⁵I-Aβ₄₀ or ¹²⁵I-Aβ₄₂ into the femoral vein. At the end of the experiment, 100μCi of ¹³¹I-albumin was injected to serve as a marker of V_p. The brain regions were dissected and assayed for radioactivity. Shown are the PS value estimates for ¹²⁵I-Aβ₄₀ (B, D) and ¹²⁵I-Aβ₄₂ (C, E) uptake at various brain regions. F) The PS values are shown for the whole brain. G) The overall brain accumulation was assessed as % ID/g. Data represent mean±SD, n = 3–5. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001; two-way ANOVA with Bonferroni post-tests).