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Plasma pharmacokinetics of 125I-insulin in WT mice at 8, 24, and 52 weeks. Mice were bolus injected with 100μCi of 125I-insulin into the femoral vein. Plasma was sampled periodically between 0–14 min, and radioactivity in the intact 125I-insulin fraction was measured. The plasma concentration versus time data was fit to a bi-exponential equation. Shown are the observed values (mean±SD, n = 3–5) overlaid on the predicted curves.
