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Plasma pharmacokinetics of 125I-insulin in WT mice at 8, 24, and 52 weeks
|
125I-insulin | |||
|---|---|---|---|
| Age (weeks) | Cmax (μCi/mL) | AUC (μCi.min/mL) | Clearance (mL/min) |
|
| |||
| 8 | 19.6 ± 0.2 | 83.7 ± 7.9 | 1.19 ± 0.11 |
| 24 | 23.5 ± 0.5**** | 170 ± 15 | 0.61 ± 0.06*** |
| 52 | 28.0 ± 0.4**** | 357 ± 68** | 0.28 ± 0.05**** |
Data represent mean±SE, n = 3–5. Significance was assessed over age (**p <0.01, ***p <0.001, ****p <0.0001; one-way ANOVA with Bonferroni post-tests).
