Table 3.
Enrichment of various transporter/signaling pathways in brain endothelial cells from WT mice at 12 and 104 weeks
| Pathway | GSVA |
GSEA |
||
|---|---|---|---|---|
| Directionality | p | Directionality | p | |
|
| ||||
| KEGG AGE RAGE Signaling Pathway | Up | 0.088 | Up | 0.25 |
| PID_Insulin Pathway | 0.035 | 0.11 | ||
| PID.PI3KCI AKT Pathway | 1.5E-08 | 0.0043 | ||
| KEGG_Type II Diabetes Mellitus | 0.012 | 0.12 | ||
| KEGG.ABC Transporters | Down | 0.0058 | Down | 0.086 |
| REACTOME_Tight Junction Interactions | 2.9E-05 | 0.13 | ||
The GSVA and GSEA methods were used to compare the enrichment of various transporter/signaling pathways in brain endothelial cells obtained from WT mice at different ages, using the single-cell RNA-Seq data published by Ximerakis et al. [21]. The directionality indicates upregulation or downregulation of the pathway in the aged compared to young mice.