Fig. 2.

Change in eGFR and albuminuria in the primary ITT analysis. a) Change in eGFR over time in the two groups (primary outcome). The table at the bottom of the panel shows the number of patients contributing with data at each time point. This is the primary analysis performed, on average on a total of 6197 patients/group contributing with eGFR values, though not all patients had available baseline eGFR. Baseline eGFR was imputed only for PSM, but imputed data were not used for outcome evaluation. b) Total and chronic (6 months on) eGFR slopes in the two groups (bars indicate 95% C.I.). c) Adjusted change in albuminuria (urinary albumin excretion rate, UACR) over time in the two groups and in the split of the population by baseline normo- (d) or micro-macroalbuminuria (e). The table at the bottom of the panel shows the number of patients contributing with data at each time point. The observation period was cut at 54 months.