Table 2.

List of increased differential metabolites (n = 6)

Name	MEAN HEK293T-OATP1B3	MEAN HEK293T-Mock	VIP	p value
1-Methylnicotinamide	0.051793105	0.046639907	2.197071492	0.006405209
Pyridoxine	0.209476199	0.058824074	2.339019443	0.032385825
L-Serine-O-sulfate	0.003277663	0.002642044	1.755664297	0.04570739
Azelaic acid	0.00038101	0.000232587	2.071560976	0.005113825
N-Acetylornithine	0.00108073	0.00058759	2.416609223	0.001055526
N-Acetyl-L-phenylalanine	0.00041701	0.00036344	2.161418253	0.009797162

MEAN OATP1B3/Mock: relative quantitative value of the metabolite in HEK293T-OATP1B3 or -Mock groups within the set of comparisons; VIP: the variable projected importance of metabolite obtained from the OPLS-DA for this group of comparisons; p value: the p value obtained from the t-test for the comparison of this metabolite in the group. OPLS-DA: orthogonal partial least squares discriminant analysis