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. 2023 Dec 16;65(3):377–402. doi: 10.1007/s12016-023-08971-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Pityriasis rubra pilaris and CARD14-associated papulosquamous eruption (CAPE). Patient with pityriasis rubra pilaris presented typical diffuse hyperkeratotic papules which progressed to erythroderma with characteristic islets of sparing, i.e., foci of uninvolved skin (a). The second patient with CARD14-activating mutation showed lesions mimicking psoriasis (b). Histology of pityriasis rubra pilaris revealing follicular plugging, preserved granular layer or hypergranulosis, and alternating areas of ortho- and parakeratosis (c)