Table 1.
Demographic, clinical, and neuropathologic characteristics of rush religious orders study cases used in Dataset 1 (A) and Dataset 2 (B).
| A | |||
|---|---|---|---|
| NCI (n = 13) |
MCI (n = 15) |
AD (n = 9) |
|
| Age at death (years) | 82.95 ± 7.70 | 85.29 ± 4.51 | 86.84 ± 6.55 |
| Education (years) | 17.46 ± 4.07 | 19.13 ± 2.17 | 17.56 ± 1.67 |
| Sex (M/F) | 7/6 | 6/9 | 2/7 |
| APOE ε4 carrier status (+/−) | 1/12 | 7/8 | 8/1 |
| MMSE | 27.85 ± 1.57 | 26.80 ± 2.73 | 20.22 ± 4.06 |
| Global cognitive score (z-score) | 0.02 ± 0.27 | −0.43 ± 0.25 | −1.59 ± 0.37 |
| Post-mortem interval (hours) | 7.45 ± 8.19 | 6.92 ± 4.01 | 7.57 ± 3.57 |
| Brain weight at autopsy (grams) | 1,245.77 ± 170.39 | 1,239.73 ± 212.03 | 1,123.75 ± 152.59 |
| CERAD No AD Possible AD Probable AD Definite AD |
7 2 2 2 |
1 2 5 7 |
0 0 3 6 |
| Braak Stage 0-II III-IV V-VI |
5 8 0 |
2 8 5 |
1 2 6 |
| B | |||
|---|---|---|---|
| NCI (n = 19) |
MCI (n = 10) |
AD (n = 17) |
|
| Age at death (years) | 85.84 ± 5.47 | 87.27 ± 5.35 | 83.86 ± 7.72 |
| Education (years) | 17.71 ± 2.87 | 17.60 ± 2.17 | 16.35 ± 3.24 |
| Sex (M/F) | 7/12 | 4/6 | 8/9 |
| APOE ε4 carrier status (+/−) | 3/16 | 4/5* | 8/8* |
| MMSE | 28.53 ± 1.58 | 26.10 ± 3.51 | 16.35 ± 3.24 |
| Global cognitive score (z-score) | −0.04 ± 0.29 | −0.54 ± 0.36 | −1.46 ± 0.40 |
| Post-mortem interval (hours) | 6.06 ± 2.41 | 6.44 ± 3.00 | 7.09 ± 3.51 |
| Brain weight at autopsy (grams) | 1,209.84 ± 140.50 | 1,186.70 ± 96.41 | 1,190.24 ± 95.75 |
| CERAD No AD Possible AD Probable AD Definite AD |
4 4 10 1 |
2 0 6 2 |
0 0 4 13 |
| Braak Stage 0-II III-IV V-VI |
8 10 1 |
1 7 2 |
0 6 11 |
NCI, no cognitive impairment; MCI, mild cognitive impairment; AD, Alzheimer’s disease; mean ± standard deviation; MCI and AD groups each had one case where APOE genotype data was not available.