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. 2024 Jan 24;15:1288362. doi: 10.3389/fphar.2024.1288362

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Copyright © 2024 Bao, Chen, Duan, Wang, Lai, Mo and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adverse events involving nervous system disorders. (A) Distribution of the total number and percentage of patients with concomitant nervous system disorders in reports of HER2 monotherapy. (B) Bar graph statistics of the proportion and number of cases of living and dead patients presenting with nervous system disorders, and those not explicitly labeled in the outcome list have been excluded. (C) Mulberry map of clinical characteristics of patients with nervous system disorders. (D) Comparison of positive signal with nervous system disorders obtained by different HER2 inhibitors based on the Proportional Reporting Ratio (PRR) method. Red dots indicate PRR values in the 2.0–6.0 range. Blue dots indicate PRR values above 5.0.