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. 2024 Feb 6;15:974. doi: 10.1038/s41467-024-44905-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Presence of donor specific allo-antibodies (DSA) was determined on day of dosing and day 14, showing induction of DSA. Patients were scored weather DSA were induced or not induced at day 14 post infusion. Small changes (<1000 MFI) in DSA measurements between D1 and D14 were scored as not induced. Incidence of DSA development is reduced with increased HLA class I matching but appears unrelated to the degree of HLA-class II matching. Mean column values compared using Mann–Whitney nonparametric test, with P values (two-tailed) indicated. B Serum levels of DSA post-dosing are reduced with increased degree of HLA matching. DSA levels of combined MFI < 1000 are considered negative and not reported. C For 4 patients (identified by different colors) DSA levels were measured at the time of discharge (day of discharge of patients, from left to right: 60, 28, 21, 28). DSA levels post infusion of agenT-797 peak at day 14 and appear to decrease afterwards (data normalized to peak DSA levels for each patient).