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. 2024 Feb 6;15:898. doi: 10.1038/s41467-024-44845-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Example of single-unit activity in a C-thermoreceptor driven by blue light stimulation (10 s), the same unit did not respond to mechanical stimulation of its receptive field. b Mean rate of firing to blue light stimulation of C-thermoreceptors (n = 7 units). c Proportion of C-thermoreceptors with a blue light response (left) and their latencies (right). d Examples traces of C-fibers responding to a ramp heating stimulus before and after yellow light exposure in Sox10-ArchT mice. e, f Heat activated responses measured as thresholds (e) and spiking rates (f) in all heat responsive fibers (C-thermoreceptors and polymodal C-fibers pooled) before and after yellow light in Sox10-ArchT mice (n = 13) compared to those from Sox10-Cre control animals (n = 9) did not differ (two-way ANOVA, P = 0.55 (threshold) and P = 0.92 (ramp response), Bonferroni’s multiple comparison test). (g) Examples traces of C-fibers responding to a ramp cooling stimulus before and after yellow light exposure in Sox10-ArchT mice. h, i Cold activated responses measured as thresholds (h) and spiking rates (i) in all cold responsive fibers (C-thermoreceptors and polymodal C-fibers pooled) before and after yellow light in Sox10-ArchT mice (n = 15) compared to those from Sox10-Cre control animals (n = 7) did not differ (two-way ANOVA, P = 0.6 (threshold) and P = 0.48 (ramp response), Bonferroni’s multiple comparison test). Data are presented as mean values ± s.e.m. Source data are provided as a Source Data file.