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. 2024 Feb 6;15:898. doi: 10.1038/s41467-024-44845-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic of the localization of Sox2 at mechanoreceptor endings. b Upper panels show a lower magnification immunohistochemistry for TOMATO (recapitulating Sox2 expression) and S100β to label glial cells in glabrous skin of Sox2-TOM hind paws. Arrowheads point to Meissner corpuscles. Lower panels show a high magnification image of an immunohistochemistry for TOMATO (recapitulating Sox10 expression), PGP9.5 to label neurons in the corpuscle sensory ending and against Sox2. Arrowhead points to a Sox2⁺/Sox10⁺ cell within the Meissner corpuscle. Scale bar: 50 μm (upper panel) and 20 μm (lower panel). Immunohistochemistry experiments were repeated at least 3 times with similar results.