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. 2024 Feb 6;10:14. doi: 10.1038/s41421-024-00648-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Vaccination schedule overview. A healthy volunteer received a total of five doses of vaccine, starting with a two-dose mRNA vaccine (BNT162b2) followed by a three-dose inactivated whole-virion vaccine (BBIBP-CorV). Blood samples were collected after the 4th and 5th vaccination dose as illustrated in the diagram. b Neutralizing antibody titers of the sequential vaccination doner (4-dose: blue and 5-dose: red) compared to the 3-dose BBIBP vaccinees (black, n = 11). Neutralizing antibody titers represent serum dilution required to achieve 50% virus neutralization (ID₅₀). The numbers indicate the fold of enhancement of ID₅₀ values relative to mean titer measured among 3-dose BBIBP vaccinees.