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. 2024 Feb 6;10:14. doi: 10.1038/s41421-024-00648-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Cryo-EM structure of the XBB S in complex with the antibody PW5-535 IgG. b Cryo-EM structures of the SARS-CoV S in complex with the antibody PW5-535 IgG. c Structure of XBB RBD–PW5-535. The RBD is displayed in tomato. The heavy chain and light chain of PW5-535 are shown as ribbons colored in dark purple and light purple, respectively. d Close-up view of the PW5-535 epitope on the XBB RBD and SARS-CoV RBD. e Detailed interactions between the PW5-535 and XBB S RBD. f PW5-535 causes steric hindrance with ACE2. g Detailed interactions between the PW5-535 and SARS-CoV S RBD and SD1. Hydrogen bonds are represented by dashed lines. Hydrophobic interactions are marked with red circles.