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. 2024 Feb 6;10:14. doi: 10.1038/s41421-024-00648-1

Fig. 8. Therapeutic efficacy of PW5-5 and PW5-535 against XBB.1 in golden Syrian hamsters.

Fig. 8

a Schematic of the in vivo mAb efficacy test experiment in hamsters. b Viral load quantification of XBB.1 in golden hamster lung and nasal turbinate with or without treatments. Lung and nasal turbinate samples were harvested on day 4 post SARS-CoV-2 Omicron XBB.1 challenge and homogenized for plaque assay titration (n = 6). c Immunofluorescence images of the whole section of infected hamster lungs with or without treatments. SARS-CoV-2 N protein was identified with a rabbit anti-SARS-CoV-2-N immune serum (green). Nuclei was identified with DAPI stain (blue). Scale bars in c represented 1000 μm for fourfold magnifications of the objective with tenfold magnification at the eyepiece. d Representative H&E images of infected hamster lungs with or without treatments. A representative region of (1) bronchiole epithelium and (2) alveolar space was shown. Scale bars in d represented 500 or 100 μm for fourfold or 20-fold magnifications of the objective, respectively, with ×10 magnification at the eyepiece. The experiments in b, d were repeated two times independently with similar results, respectively. Data represented mean ± SEM from the indicated number of biological repeats. Statistical significance between groups in b was determined with one-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.