Fig. 1.

Phenotypic characterization of broad immune cell types of psoriasis PBMCs (n = 31) vs. healthy donors (n = 32). (a) UMAP plots of PBMCs (2000 subsampled cells from each sample) aggregated across all healthy donor and psoriasis samples (total of 32,000 cells in each cohort) with the colour corresponding to the annotated cell population shown in panel B. (b) Heatmap of the median marker expression for each annotated cell type. (c) Overlaid violin and swarm plots of significantly differing immune cell population frequencies (% of total live CD45+ cells) between healthy control and psoriasis samples. An asterisk indicates a significantly differing cell population frequency with an adjusted p < 0.05. ∗adj. p < 0.05, ∗∗adj. p < 0.01, ∗∗∗adj. p < 0.001, ∗∗∗∗adj. p < 0.0001.