FIGURE 2.

Cell type and spatial neighborhood generation in the simulation study: (A) An illustration of the spatial distribution of different cell types in the simulated cell-level ST data under the homogeneous simulation setting. The pie plot further summarizes the cell type proportions. (B) An illustration of the spatial distribution of different cell types in the simulated cell-level ST data under the heterogeneous simulation setting. The pie plots further summarize the cell type proportions in the two different domains. (C) An illustration of the index cell and its neighborhood region in the simulation. (D) An illustration of the index spot and its neighborhood region after cell-level data is aggregated to the spot-level.