Figure 2.

Humoral immune response to delandistrogene moxeparvovec

Anti-AAVrh74 antibody levels at various time points following initial dose (left of dashed line) and redosing (right of dashed line) of delandistrogene moxeparvovec for cohorts 2–4 (A) and cohort 5 (B). Animals in cohort 5 did not receive plasmapheresis. Vertical dotted line delineates part 1 from part 2. Horizontal dashed line delineates the threshold for 1:400, which indicates positive antibody titer response. (C) IgM response at 2 weeks after initial dose of GTT (part 1) and at 1 and 2 weeks post-redosing of GTT (part 2). Error bars are SEM and represents three animal samples per cohort run.