TABLE 1.
C. neoformans 184 yeast burdens in the organs of aged and young adult B6D2F1 mice after intravenous infection
| Mice | Log10 CFU/organ (mean ± SD)a
|
||||
|---|---|---|---|---|---|
| Liver | Lung | Kidney | Spleen | Brain | |
| 10 days | |||||
| Aged | 3.69 ± 0.31 | 2.69 ± 0.76 | 3.08 ± 1.45 | 2.49 ± 0.70 | 5.97 ± 0.92 |
| Young adult | 3.15 ± 0.39 | 1.94 ± 0.46 | 2.36 ± 0.46 | 2.00 ± 0.35 | 5.49 ± 0.61 |
| 14 days | |||||
| Aged | 4.98 ± 1.12 | 3.07 ± 0.78 | 3.97 ± 0.84 | 3.85 ± 1.85 | 7.40 ± 0.03 |
| Young adult | 3.65 ± 0.47* | 2.18 ± 0.69 | 2.43 ± 1.10 | 2.27 ± 0.65 | 6.16 ± 0.76* |
a
Female mice were given 2 × 104 strain 184 yeast cells intravenously. Groups of mice were killed at 10 and 14 days of infection. For aged mice, n = 4; for young adults, n = 5. ∗, differs significantly from aged group (P < 0.05).