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. 2024 Feb 7;13:14. doi: 10.1186/s40164-024-00484-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Resistant tumor cells acquire elevated proliferation rates. A Left: UMAP visualization of B cells colored by inferred cell cycle stages (G1, S, G2/M). Right: UMAP visualizations of B cells divided by clinical outcome: sensitive (BTKi-Fast and BTKi-Slow) and resistant (BTKi-R and Dual-R). Each dot represents one cell. Gray, orange, and red represent G1, S, and G2M cell cycle stages, respectively. B Boxplot shows inferred proliferation rates (y-axis) across clinical outcomes (x-axis) in single-cell RNA-seq dataset. Each dot represents one sample and is colored by clinical outcome. P-value was calculated using a generalized binomial model. C Boxplot shows proliferation rates as indicated by Ki-67-positive immunohistochemical staining across clinical outcomes from clinical pathologic data. Each dot represents one patient and is colored by clinical outcome. D Representative bone marrow images stained with hematoxylin and eosin (upper panels) or immunohistochemically stained for cyclin D1 (middle panels) or Ki-67 (bottom panels) on samples from representative patients D (BTKi-Fast), AA (BTKi-Slow), Q (BTKi-R), and A (Dual-R)