Table 2.
Associations of cardiometabolic disease status and CSF AD biomarkers in cognitively intact participants
| Variable | Aβ42 | P-tau181 | T-tau | Aβ42/Aβ40 | P-tau181 /Aβ42 | T-tau/Aβ42 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | P value | β | P value | β | P value | β | P value | β | P value | β | P value | |
| Number of CMD (continuous) | 0.070 | 0.504 | 0.078 | 0.044 | 0.030 | 0.047 | −0.007 | 0.637 | 0.007 | 0.879 | 0.012 | 0.661 |
| CMD status | ||||||||||||
| CMD-free (n = 700) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | ||||||
| Single CMD (n = 454) | −0.036 | 0.840 | 0.047 | 0.475 | 0.009 | 0.721 | −0.008 | 0.751 | 0.049 | 0.528 | 0.020 | 0.670 |
| CMD multimorbidity (n = 310) | 0.170 | 0.428 | 0.165 | 0.037 | 0.065 | 0.033 | −0.014 | 0.650 | 0.002 | 0.981 | 0.022 | 0.696 |
Adjusted for age, sex, education years, MMSE, APOE ε4 carrier status, BMI, cigarette use, alcohol use, and physical activity. The statistically significant results were bolded
Abbreviations: CMD Cardiometabolic disease, MMSE Mini-Mental State Examination, APOE Apolipoprotein E, BMI Body mass index