Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 7;25:45. doi: 10.1186/s13059-024-03172-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — A The distribution of integrated value of influence (IVI) scores for different gene sets, calculated from log2FC (fold change in expression from recurrent to primary) correlation networks, for Down (purple) and Up (gold) responders. nonJBS: genes not in the JARID2 gene set; JBS: genes in the JARID2 gene set but excluding those in the leading edge of at least 50% of patients (LE50 genes); LE50: genes in the LE50 gene set but excluding those in the LE70 gene set; LE70: genes in the leading edge of at least 70% of patients. B As panel A except correlation networks were built from gene expression data in primary (salmon pink) or recurrent (teal) tumors in Down (left panel) or Up (right panel) responders, separately. C Genes are plotted according to their IVI score in log2FC networks of Down (x-axis) and Up (y-axis) responders. Genes that are high in both, or uniquely high in one, log2FC network are labeled. D The expression values for genes encoding Kinesin Family Member 14 (KIF14: left image) and Myelin Basic Protein (MBP: right image) are shown in the primary (salmon pink) and recurrent (teal) tumors of Down (D) and Up (U) responders. Gray lines indicate expression values in primary and recurrent GBMs from the same patient. Significance is denoted: ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001