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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Radiother Oncol. 2023 Mar 27;183:109641. doi: 10.1016/j.radonc.2023.109641

Table 2.

ADC parameter changes at mid-RT versus baseline values.

ADC parameter (x10−3
mm2/s)
End-RT response Baseline GTV-P Mid-RT GTV-P P value Baseline GTV-N Mid-RT GTV-N P value

ADC Mean CR 1.37±0.2 1.8±0.3 <0.0001 1.27±0.3 1.6±0.4 <0.0001
Non-CR 1.3±0.2 1.6±0.4 0.07 1.28±0.3 1.54±0.3 0.01
ADC 5th percentile CR 0.87±0.3 1.2±0.3 <0.0001 0.76±0.2 1.04±0.3 <0.0001
Non-CR 1.1±0.6 1.3±0.5 0.4 1.02±0.4 1.19±0.3 0.2
ADC 10th percentile CR 0.97±0.3 1.32±0.3 <0.0001 0.86±0.2 1.16±0.3 <0.0001
Non-CR 1.2±0.5 1.42±0.4 0.3 1.06±0.3 1.26±0.2 0.02
ADC 20th percentile CR 1.1±0.3 1.47±0.3 <0.0001 0.97±0.3 1.3±0.4 <0.0001
Non-CR 1.2±0.4 1.47±0.3 0.4 1.11±0.3 1.34±0.2 0.01
ADC 30th percentile CR 1.17±0.3 1.58±0.3 <0.0001 1.06±0.3 1.4±0.4 <0.0001
Non-CR 1.2±0.3 1.5±0.3 0.3 1.16±0.2 1.4±0.1 0.009
ADC 40th percentile CR 1.25±0.3 1.68±0.3 <0.0001 1.14±0.3 1.5±0.4 <0.0001
Non-CR 1.22±0.3 1.56±0.3 0. 1.21±0.2 1.45±0.2 0.01
ADC Median CR 1.35±0.2 1.8±0.3 <0.0001 1.22±0.3 1.58±0.4 <0.0001
Non-CR 1.25±0.2 1.6±0.2 0.07 1.25±0.3 1.51±0.2 0.009
ADC 60th percentile CR 1.42±0.3 1.9±0.4 <0.0001 1.32±0.4 1.67±0.4 <0.0001
Non-CR 1.3±0.2 1.68±0.5 0.1 1.3±0.3 1.57±0.3 0.009
ADC 70th percentile CR 1.52±0.3 1.95±0.4 <0.0001 1.43±0.4 1.78±0.5 <0.0001
Non-CR 1.36±0.3 1.7±0.6 0.1 1.36±0.4 1.64±0.4 0.009
ADC 80th percentile CR 1.6±0.3 2.1±0.4 <0.0001 1.57±0.4 1.91±0.5 <0.0001
Non-CR 1.4±0.3 1.8±0.7 0.07 1.45±0.4 1.72±0.5 0.01
ADC 90th percentile CR 1.79±0.4 2.22±0.4 <0.0001 1.76±0.4 2.07±0.5 <0.0001
Non-CR 1.52±0.4 1.99±0.8 0.03 1.57±0.5 1.84±0.6 0.1
ADC 95th percentile CR 1.9±0.4 2.36±0.5 <0.0001 1.93±0.4 2.2±0.5 <0.0001
Non-CR 1.61±0.6 2.09±0.9 0.03 1.65±0.7 1.97±0.8 0.1